MERCK & CO. INC.

CAIXABANK MULTISALUD, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 8.07% GESIURIS HEALTHCARE & INNOVATION FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 4.58% IBERCAJA SANIDAD, FI IBERCAJA GESTION, SGIIC, S.A. 4.00% TOP CLASS HEALTHCARE, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 3.69% RENTA 4 MEGATENDENCIAS, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 3.38% SIGMA INVESTMENT HOUSE HEALTHCARE, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 3.07% RENTA 4 EEUU ACCIONES, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 2.78% GESTION BOUTIQUE VI, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 2.72% IBERCAJA MEGATRENDS, FI IBERCAJA GESTION, SGIIC, S.A. 2.20% CAIXABANK GESTIÓN TENDENCIAS, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 1.99% BALTIA GLOBAL,FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 1.73% ALGAR GLOBAL FUND, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 1.57% BANKINTER SOSTENIBILIDAD, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 1.56% TOP CLASS GLOBAL EQUITY, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 1.51% BESTINVER NORTEAMÉRICA, FI BESTINVER GESTION, S.A., S.G.I.I.C. 1.50% FONDMAPFRE BOLSA AMERICA, FI MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 1.46% MAGNUS INTERNATIONAL ALLOCATION, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 1.45% KUTXABANK BOLSA EEUU, FI KUTXABANK GESTION, SGIIC, S.A. 1.44% GESIURIS PATRIMONIAL, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 1.34% MARCH RENTA VARIABLE NORTEAMERICA, FI MARCH ASSET MANAGEMENT, S.G.I.I.C., S.A.U. 1.29% IBERCAJA GLOBAL BRANDS, FI IBERCAJA GESTION, SGIIC, S.A. 1.29% IBERCAJA DIVIDENDO GLOBAL, FI IBERCAJA GESTION, SGIIC, S.A. 1.29% IBERCAJA BOLSA USA, FI IBERCAJA GESTION, SGIIC, S.A. 1.27% BBVA USA DESARROLLO, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 1.23% MULTIADVISOR GESTION, FI INVERSIS GESTIÓN, S.A., SGIIC 1.23% BBVA USA DESARROLLO CUBIERTO, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 1.23% BEST IDEAS, FI MARCH ASSET MANAGEMENT, S.G.I.I.C., S.A.U. 1.21% MUTUAFONDO RENTA VARIABLE EE.UU, FI MUTUACTIVOS, S.A., S.G.I.I.C. 1.19% GVCGAESCO T.F.T., FI GVC GAESCO GESTIÓN, SGIIC, S.A. 1.18% KUTXABANK BOLSA TENDENCIAS CARTERAS, FI KUTXABANK GESTION, SGIIC, S.A. 1.12% RENTA 4 WERTEFINDER, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 1.03% OCCIDENT PATRIMONIO, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 1.02% BT FUND, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 0.95% SMART GESTION FLEXIBLE, FI INVERSIS GESTIÓN, S.A., SGIIC 0.93% BBVA GLOBAL DESARROLLO, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 0.92% RURAL ESTADOS UNIDOS BOLSA, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 0.82% BBVA MEGATENDENCIA DEMOGRAFIA, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 0.81% GCO BOLSA USA, FI GRUPO CATALANA OCCIDENTE GESTION DE ACTIVOS, S.A., SGIIC 0.74% IBERCAJA BOLSA INTERNACIONAL, FI IBERCAJA GESTION, SGIIC, S.A. 0.70% ALBUS, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 0.66% RURAL FUTURO ISR, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 0.64% BINDEX USA SCREENED ÍNDICE (CUBIERTO), FI BBVA ASSET MANAGEMENT, S.A., SGIIC 0.63% GCO INTERNACIONAL, FI GRUPO CATALANA OCCIDENTE GESTION DE ACTIVOS, S.A., SGIIC 0.48% BINDEX USA INDICE, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 0.43% ING DIRECT FONDO NARANJA STANDARD & POOR´S 500, FI AMUNDI IBERIA, SGIIC, S.A. 0.43% BBVA BOLSA INDICE USA (CUBIERTO), FI BBVA ASSET MANAGEMENT, S.A., SGIIC 0.43% SIGMA INVESTMENT HOUSE CAPITAL, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 0.42% IBERCAJA SOSTENIBLE Y SOLIDARIO, FI IBERCAJA GESTION, SGIIC, S.A. 0.36% FONDMAPFRE GLOBAL, FI MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 0.36% CINVEST MULTIGESTION FI GESALCALA, S.A., S.G.I.I.C. 0.30% TARFONDO, FI AMUNDI IBERIA, SGIIC, S.A. 0.29% IBERCAJA CONFIANZA SOSTENIBLE, FI IBERCAJA GESTION, SGIIC, S.A. 0.26% FONDMAPFRE RENTA MIXTO, FI MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 0.26% GCO GLOBAL 50, FI GRUPO CATALANA OCCIDENTE GESTION DE ACTIVOS, S.A., SGIIC 0.22% GCO MIXTO, FI GRUPO CATALANA OCCIDENTE GESTION DE ACTIVOS, S.A., SGIIC 0.21% ATL CAPITAL CARTERA DINAMICA, FI ATL 12 CAPITAL GESTION S.G.I.I.C, S.A. 0.16% RURAL MIXTO INTERNACIONAL 30/50, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 0.15% INVERSABADELL 70, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 0.15% INVERSABADELL 50, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 0.11% FONDMAPFRE ELECCION PRUDENTE, F.I. MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 0.10% MARKET PORTFOLIO EQUITY, F.I. MARKET PORTFOLIO ASSET MANAGEMENT, S.G.I.I.C., S.A. 0.08% FONDMAPFRE ELECCIÓN DECIDIDA, F.I. MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 0.08% FONDMAPFRE ELECCION MODERADA, F.I. MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 0.06% INVERSABADELL 25, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 0.05% SABADELL PLANIFICACION, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 0.05%