ROCHE HOLDING AG

BOWCAPITAL GLOBAL FUND, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 9.55% PATRISA, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 7.13% SANTANDER DIVIDENDO EUROPA, FI SANTANDER ASSET MANAGEMENT, S.A., SGIIC 7.09% CAIXABANK BOLSA DIVIDENDO EUROPA, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 6.83% GESIURIS HEALTHCARE & INNOVATION FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 5.76% BBVA MI INVERSION BOLSA, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 5.54% BBVA MI INVERSION BOLSA ACUMULACION, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 5.52% BBVA BOLSA PLAN DIVIDENDO EUROPA, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 5.51% GVC GAESCO DIVIDEND FOCUS, F.I. GVC GAESCO GESTIÓN, SGIIC, S.A. 4.80% FENIX GLOBAL MULTIASSETS, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 4.48% GVC GAESCO CONSCIOUS BUSINESS EQUITY FUND, FI GVC GAESCO GESTIÓN, SGIIC, S.A. 4.46% CBNK SELECCIÓN, FI CBNK GESTION DE ACTIVOS, S.G.I.I.C., S.A. 4.24% ABANCA RENTA VARIABLE DIVIDENDO, FI ABANCA GESTION DE ACTIVOS, SGIIC, SA 4.23% CAIXABANK BOLSA GESTION EUROPA, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 4.00% FONDMAPFRE BOLSA EUROPA, FI MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 3.92% IBERCAJA SANIDAD, FI IBERCAJA GESTION, SGIIC, S.A. 3.88% BRIGHTGATE-IAPETUS EQUITY, FI BRIGHTGATE CAPITAL, S.G.I.I.C., S.A. 3.85% CAIXABANK MULTISALUD, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 3.75% MERCH-EUROUNION, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 3.72% CAIXABANK MASTER RENTA VARIABLE EUROPA, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 3.71% UBS FAMILY BUSINESS, FI UBS WEALTH MANAGEMENT, S.G.I.I.C., S.A. 3.70% TOP CLASS HEALTHCARE, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 3.70% SABADELL EUROPA BOLSA FUTURO, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 3.59% SIGMA INVESTMENT HOUSE HEALTHCARE, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 3.39% RENTA 4 MEGATENDENCIAS, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 3.25% NAO RENTA VARIABLE EUROPA, FI NAO ASSET MANAGEMENT, E.S.G. SGIIC, S.A. 3.22% MI CARTERA RV EUROPA, FI SANTANDER ASSET MANAGEMENT, S.A., SGIIC 3.16% SANTALUCIA QUALITY ACCIONES EUROPEAS, FI SANTA LUCIA ASSET MANAGEMENT, SGIIC, S.A. 3.03% RENTA 4 EUROPA ACCIONES, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 3.01% IBERCAJA DIVIDENDO GLOBAL, FI IBERCAJA GESTION, SGIIC, S.A. 2.95% FONDMAPFRE BOLSA MIXTO, FI MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 2.92% MARCONI, FI MUTUACTIVOS, S.A., S.G.I.I.C. 2.87% BBVA MI INVERSION MIXTA, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 2.80% BBVA EUROPA DESARROLLO, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 2.79% WELZIA SELECTIVE, FI WELZIA MANAGEMENT, SGIIC, S.A. 2.69% RENTA 4 GLOBAL, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 2.63% GVC GAESCO EUROPA, FI GVC GAESCO GESTIÓN, SGIIC, S.A. 2.60% CARTESIO Y, FI CARTESIO INVERSIONES, SGIIC, S.A. 2.59% ALTAIR EUROPEAN OPPORTUNITIES, FI SOLVENTIS S.G.I.I.C., S.A. 2.58% ABANCA RENTA VARIABLE MIXTA, FI ABANCA GESTION DE ACTIVOS, SGIIC, SA 2.54% RHO SELECCION, FI SINGULAR ASSET MANAGEMENT, SGIIC, S.A. 2.40% IBERCAJA BOLSA EUROPA, FI IBERCAJA GESTION, SGIIC, S.A. 2.36% LIERDE EQUITIES, F.I. AUGUSTUS CAPITAL ASSET MANAGEMENT, SGIIC, S.A. 2.33% CAIXABANK GESTIÓN TENDENCIAS, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 2.24% BINDEX EUROPA CTB INDICE, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 2.21% BBVA BOLSA EUROPA, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 2.13% DIUKES GLOBAL SELECTION FUND, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 2.09% MERCH-FONTEMAR, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 2.08% BESTINVER MEGATENDENCIAS, FI BESTINVER GESTION, S.A., S.G.I.I.C. 2.05% MERCH-UNIVERSAL, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 2.05% BINDEX EUROPA INDICE, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 2.04% GESTION BOUTIQUE VI, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 1.96% MICROBANK FONDO ETICO, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 1.95% GESIURIS PATRIMONIAL, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 1.88% PATRIVAL, FI PATRIVALOR, SGIIC, S.A. 1.84% BANKINTER MIXTO FLEXIBLE, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 1.84% RENTA 4 UNIVERSAL, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 1.83% MARCH GLOBAL QUALITY, FI MARCH ASSET MANAGEMENT, S.G.I.I.C., S.A.U. 1.80% BANKINTER DIVIDENDO EUROPA, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 1.78% FINACCESS COMPROMISO SOCIAL EUROPA RV, FI AFI INVERSIONES GLOBALES, SGIIC, S.A. 1.74% TOGAEST INVERSIONES, FI DUX INVERSORES, SGIIC, S.A. 1.57% PATRIBOND, FI PATRIVALOR, SGIIC, S.A. 1.57% MERCHFONDO, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 1.56% CAIXABANK BOLSA IMPROVERS, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 1.51% PSN MULTIESTRATEGIA, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 1.48% UBS PREMIUM DINÁMICO, FI UBS WEALTH MANAGEMENT, S.G.I.I.C., S.A. 1.47% MARKET PORTFOLIO EQUITY, F.I. MARKET PORTFOLIO ASSET MANAGEMENT, S.G.I.I.C., S.A. 1.47% MULTIADVISOR GESTION, FI INVERSIS GESTIÓN, S.A., SGIIC 1.42% DEIDAD, FI INVERSIS GESTIÓN, S.A., SGIIC 1.40% GESCONSULT RENTA VARIABLE EUROZONA, FI GESCONSULT, S.A., S.G.I.I.C. 1.38% DB BOLSA GLOBAL, FI DEUTSCHE WEALTH MANAGEMENT SGIIC, S.A. 1.31% DUX INTERNATIONAL STRATEGY, FI ABANTE ASESORES GESTION, SGIIC, S.A. 1.29% BBVA MEGATENDENCIA DEMOGRAFIA, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 1.26% WELZIA COYUNTURA, FI WELZIA MANAGEMENT, SGIIC, S.A. 1.25% MULTIADVISOR GESTION, FI INVERSIS GESTIÓN, S.A., SGIIC 1.24% BEST IDEAS, FI MARCH ASSET MANAGEMENT, S.G.I.I.C., S.A.U. 1.24% OCCIDENT PATRIMONIO, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 1.21% FONDGUISSONA GLOBAL BOLSA, FI GVC GAESCO GESTIÓN, SGIIC, S.A. 1.20% SILVERBACK, FI ATL 12 CAPITAL GESTION S.G.I.I.C, S.A. 1.19% BANKINTER MULTI-ASSET INVESTMENT, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 1.14% GREDOS BOLSA EURO, FI A&G FONDOS, SGIIC, SA 1.12% DUX UMBRELLA, FI DUX INVERSORES, SGIIC, S.A. 1.12% OLYMPUS EQUITY EUROPE, FI ATL 12 CAPITAL GESTION S.G.I.I.C, S.A. 1.12% TOP CLASS GLOBAL EQUITY, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 1.11% RURAL FUTURO ISR, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 1.10% SMART GESTION FLEXIBLE, FI INVERSIS GESTIÓN, S.A., SGIIC 1.08% SWM ESTRATEGIA RENTA VARIABLE,FI SINGULAR ASSET MANAGEMENT, SGIIC, S.A. 1.06% UBS PREMIUM EQUILIBRADO, FI UBS WEALTH MANAGEMENT, S.G.I.I.C., S.A. 1.04% GVCGAESCO T.F.T., FI GVC GAESCO GESTIÓN, SGIIC, S.A. 1.03% CBNK DIVIDENDO EURO, FI CBNK GESTION DE ACTIVOS, S.G.I.I.C., S.A. 1.03% CAIXABANK SMART RENTA VARIABLE EUROPA, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 1.02% TREA CAJAMAR RENTA VARIABLE INTERNACIONAL FI TREA ASSET MANAGEMENT S.G.I.I.C., S.A. 1.02% RENTA 4 ACTIVOS GLOBALES, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 1.02% GESIURIS BALANCED EURO, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 1.01% GVC GAESCO CROSSOVER, FI GVC GAESCO GESTIÓN, SGIIC, S.A. 0.96% TREA GLOBAL FLEXIBLE, FI TREA ASSET MANAGEMENT S.G.I.I.C., S.A. 0.96% SA OPTIMA GLOBAL, FI SILVER ALPHA ASSET MANAGEMENT SGIIC, S.A. 0.96% LAMBDA UNIVERSAL, FI SINGULAR ASSET MANAGEMENT, SGIIC, S.A. 0.95% MEDIOLANUM RENTA VARIABLE GLOBAL SELECCIÓN, FI MEDIOLANUM GESTION, S.G.I.I.C., S.A. 0.92% ANNUALCYCLES STRATEGIES, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 0.92% GVCGAESCO MULTINACIONAL, FI GVC GAESCO GESTIÓN, SGIIC, S.A. 0.89% DUX MIXTO VARIABLE, FI ABANTE ASESORES GESTION, SGIIC, S.A. 0.88% BBVA GLOBAL DESARROLLO, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 0.88% KUTXABANK BOLSA TENDENCIAS CARTERAS, FI KUTXABANK GESTION, SGIIC, S.A. 0.87% RURAL RENTA VARIABLE INTERNACIONAL, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 0.86% DEEP VALUE INTERNATIONAL, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 0.86% QUANTOP, FI UBS WEALTH MANAGEMENT, S.G.I.I.C., S.A. 0.85% ABANCA RENTA FIJA MIXTA, FI ABANCA GESTION DE ACTIVOS, SGIIC, SA 0.85% CREAND GLOBAL, FI GESALCALA, S.A., S.G.I.I.C. 0.83% GESIURIS EURO EQUITIES, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 0.81% GLOBAL VALUE SELECTION FI SINGULAR ASSET MANAGEMENT, SGIIC, S.A. 0.78% RENTA 4 WERTEFINDER, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 0.78% RURAL PLAN INVERSION, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 0.76% DUX UMBRELLA, FI DUX INVERSORES, SGIIC, S.A. 0.76% IBERCAJA SOSTENIBLE Y SOLIDARIO, FI IBERCAJA GESTION, SGIIC, S.A. 0.76% RENTA 4 GLOBAL DYNAMIC, FI RENTA 4 GESTORA, S.G.I.I.C., S.A. 0.75% BANKINTER MIXTO RENTA FIJA, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 0.73% BANKINTER PREMIUM AGRESIVO, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 0.71% ALBUS, FI CAIXABANK ASSET MANAGEMENT SGIIC, S.A. 0.67% IBERCAJA GLOBAL BRANDS, FI IBERCAJA GESTION, SGIIC, S.A. 0.66% GESIURIS IURISFOND, FI GESIURIS ASSET MANAGEMENT, SGIIC, S.A. 0.65% UBS PREMIUM MODERADO, FI UBS WEALTH MANAGEMENT, S.G.I.I.C., S.A. 0.55% ANTA QUALITY RENTA VARIABLE GLOBAL, FI ANTA ASSET MANAGEMENT SGIIC, SOCIEDAD ANÓNIMA 0.55% MUTUAFONDO CRECIMIENTO, FI MUTUACTIVOS, S.A., S.G.I.I.C. 0.53% SWM GLOBAL FLEXIBLE,FI SINGULAR ASSET MANAGEMENT, SGIIC, S.A. 0.52% FONDMAPFRE RENTA MIXTO, FI MAPFRE ASSET MANAGEMENT, SGIIC, S.A. 0.51% MARCH FLEXIBLE MAX 30, FI MARCH ASSET MANAGEMENT, S.G.I.I.C., S.A.U. 0.48% IBERCAJA CONFIANZA SOSTENIBLE, FI IBERCAJA GESTION, SGIIC, S.A. 0.48% BANKINTER PREMIUM DINAMICO, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 0.48% CARTESIO X, FI CARTESIO INVERSIONES, SGIIC, S.A. 0.46% DUX MIXTO MODERADO, FI ABANTE ASESORES GESTION, SGIIC, S.A. 0.45% MURANO CRECIMIENTO, FI MUTUACTIVOS, S.A., S.G.I.I.C. 0.44% SIGMA INVESTMENT HOUSE CAPITAL, FI ANDBANK WEALTH MANAGEMENT, SGIIC, S.A.U. 0.43% UNIFOND EUROPA DIVIDENDOS, FI UNICAJA ASSET MANAGEMENT, S.G.I.I.C., S.A. 0.38% BANKINTER PREMIUM MODERADO, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 0.33% BBVA MI INVERSION RF MIXTA, FI BBVA ASSET MANAGEMENT, S.A., SGIIC 0.32% RURAL MIXTO INTERNACIONAL 25, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 0.31% GLOBAL FLEXIBLE ALLOCATION, FI GESALCALA, S.A., S.G.I.I.C. 0.31% FINECO INVESTMENT OFFICE, FI G.I.I.C. FINECO, S.A., S.G.I.I.C. 0.28% TREA RENTA FIJA MIXTA, FI TREA ASSET MANAGEMENT S.G.I.I.C., S.A. 0.26% INVERSABADELL 70, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 0.25% TALENTA GLOBAL INVESTMENTS, FI TALENTA GESTION , SGIIC, S.A. 0.24% ING DIRECT FONDO NARANJA DINAMICO, FI AMUNDI IBERIA, SGIIC, S.A. 0.22% MUTUAFONDO RENTA VARIABLE INTERNACIONAL, FI MUTUACTIVOS, S.A., S.G.I.I.C. 0.21% INVERSABADELL 50, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 0.19% MURANO PATRIMONIO, FI MUTUACTIVOS, S.A., S.G.I.I.C. 0.16% BANKINTER PREMIUM CONSERVADOR, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 0.16% ATL CAPITAL CARTERA DINAMICA, FI ATL 12 CAPITAL GESTION S.G.I.I.C, S.A. 0.15% RURAL MIXTO INTERNACIONAL 15, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 0.12% RURAL MIXTO INTERNACIONAL 30/50, FI GESCOOPERATIVO, S.A., S.G.I.I.C. 0.11% ING DIRECT FONDO NARANJA MODERADO, FI AMUNDI IBERIA, SGIIC, S.A. 0.11% UNIFOND PATRIMONIO, FI UNICAJA ASSET MANAGEMENT, S.G.I.I.C., S.A. 0.10% INVERSABADELL 25, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 0.09% SABADELL PLANIFICACION, FI SABADELL ASSET MANAGEMENT, S.A., S.G.I.I.C. 0.09% GCO INTERNACIONAL, FI GRUPO CATALANA OCCIDENTE GESTION DE ACTIVOS, S.A., SGIIC 0.05% BANKINTER PREMIUM DEFENSIVO, FI BANKINTER GESTION DE ACTIVOS, S.A., S.G.I.I.C. 0.04% ING DIRECT FONDO NARANJA CONSERVADOR, FI AMUNDI IBERIA, SGIIC, S.A. 0.04%